Dr. Řádek

Lapacho Body Lotion

Use of this product is recommended especially for individuals with problematic skin prone to acne and fungal, viral, and/or bacterial diseases of the skin

Packaging:

Dose 250ml

Composition:

Aqua, Paraffinum Perliquidum, Tabebuia Impetiginosa Extr., Petrolatum, Glycerin, Cetyl and Stearyl Alcohol, Alkyl Benzoane, Dimeticone, Urea, Sweet Almond Oil, Glycine Soja Oil, D-Panthenol, Dehydroacetic Acid, Xanthan Gum, Tocopherol, Retinol Palmitane, Ascorbyl Palmitane, Polyacrylamide, Glycereth-2 Cocoate, Isoparaffin, Sodium Laureth Sulfate, Laureth-4, BHT, Benzyl Alcohol, Parféme Celesty, Jasmonal, Linalol, Alcool Benzylique, Isorandeine, Lilia, Limonene

Recommended Dosage:

Apply the product to the skin and massage in gently. Since the product contains pure plant extracts, only a small amount should be applied to avoid color staining of clothes.

Effects:

Body lotion with Tabebuia impetiginosa (Lapacho) extract helps maintain a healthy appearance of the skin. Active ingredients contained in the plant have strong antiviral, antibacterial, antifungal, and anti-inflammatory effects. In addition, they beneficially regulate moisture control and slow the aging of the skin. Body lotion regulates the size of skin pores, and refines and smoothes the surface of skin. Use of this product is recommended especially for individuals with problematic skin prone to acne and fungal, viral, and/or bacterial diseases of the skin. The product can be beneficially combined with Acne Protect and SkinProtect tablets.

More...:

Potential antipsoriatic agents: lapacho compounds as potent inhibitors of HaCaT cell growth.
Muller K, Sellmer A, Wiegrebe W.
Institut fur Pharmazeutische Chemie, Westfalische Wilhelms-Universitat Munster, Hittorfstrasse 58-62, D-48149 Munster, Germany. kmuller@uni-muenster.de
J Nat Prod. 1999 Aug;62(8):1134-6.
A number of lapacho compounds, representing the most common constituents of the inner bark of Tabebuia impetiginosa, together with some synthetic analogues, were evaluated in vitro against the growth of the human keratinocyte cell line HaCaT. With an IC(50) value of 0.7 microM, beta-lapachone (4) displayed activity comparable to that of the antipsoriatic drug anthralin. 2-Acetyl-8-hydroxynaphtho[2,3-b]furan-4,9-dione (7), which was prepared in a four-step synthesis from 2,8-dihydroxy-1, 4-naphthoquinone, was the most potent inhibitor among the known lapacho-derived compounds and inhibited cell growth with an IC(50) value of 0.35 microM. Furthermore, other active constituents of lapacho inhibited keratinocyte growth, with IC(50) values in the range of 0.5-3.0 microM. However, as already observed with anthralin, treatment of HaCaT cells with these potent lapacho compounds also caused remarkable damage to the plasma membrane. This was documented by leakage of lactate dehydrogenase into the culture medium, which significantly exceeded that of the vehicle control. Because of their potent activity against the growth of human keratinocytes, some lapacho-derived compounds appear to be promising as effective antipsoriatic agents.

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