Dr. Řádek

LivProtect Sirup

It favourably supports the physiological function of liver and increases their detoxicative abilities. It favourably acts during states after infectious and chronic liver illness. It shows hepatoprotective effects.

Packaging:

Dose 100ml

Composition:

Volume: 100ml Composition: Distilled water,Sorbitol,Glycerine,Microcrystalic cellulose,Acesulpham potassium, Neohesperidin, Hydrgen phosphate, Chanca Piedra-Phyllantus niruri extr.,Oleum anisi,Kapari- Caparis spinosa extr.,Roiibos-Aspalathus linearis extr.,Chicory-Cichorium intybus extr.,Terminalia arjuna extr.,Andrographis paniculata extr.,Xanthan gum, Sorbic acid, Benzoate sodium Preserving agents: Sorbic acid, Benzoate sodium Artificial sweetener: Acesulpham K,Neohesperidin 100 ml volume:stand.extracts Phyllantus niruri 500mg, Caparis spinosa 250mg, Aspalathus linearis 250mg,Cichorium intybus 250mg,Terminalia arjuna 250mg,Andrographis paniculata 250mg

Recommended Dosage:

Children from 3 to 6 twice a day 2 ml
Children from 6 to 12 twice a day 4 ml

Effects:

It favourably supports the physiological function of liver and increases their detoxicative abilities. It favourably acts during states after infectious and chronic liver illness. It shows hepatoprotective effects. It stimulates the natural effectiveness of the regeneration of the parenchyma liver cells. It reduces the negative impact of toxic substances and other metabolite on the liver function. Substances contained in the extract have strong antiviral effects. The product is especially suitable during chronic liver, metabolic and dyspeptic troubles of digestive tract. It also shows strong antioxidant effects reducing the negative influence of free radicals on the organism.

More...:

Liv Protect
Mgr. Katerina Horackova, Clinical department director

Liv Protect is a dietary supplement. It supports physiological liver function. It shows detoxication and hepatoprotective effects. It stimulates natural regeneration of liver parenchyme. It causes decrease of toxic substances and their metabolits negative activity on liver function. This preparative is suitable as a supplement by chronical liver and metabolic diseases and after viral liver diseases (hepatitis, glandular fever). It contains: Phyllanthus tenellus Extr., Terminalia arjuna Extr., Cichorium intybus Extr, Capparis spinosa Extr, Emblica officinalis Extr, Achilea millefolium Extr, Tamarix gallica Extr, Andrographis paniculata Extr, Tabebuia serratifolia Extr.

Characteristic of compounds:

Phylanthus tenellus
This extract has strong hepatoprotective activity. There were made many studies manifesting this effect. A study has been made in year 2006, influence of plant on nimesulide induced oxidative stress and hepatoprotective effect in mice has been examined. As a comparative antioxidant vitamin E has been used. This study has shown the hepatoprotective effect just because of antioxidant activity of used plant fraction.1
Next study from year 2006 shows lipid peroxidation inhibition and free radical scavenging in vitro and hepatoprotective activity after CCl4 administration in vivo.2
Extract inhibits endogenous DNA polymerase of hepatitis B virus and binds it to the antigen surface of hepatitis B in vitro.3
A decrease of LDL and VLDL levels in rats has been showed, this decrease is caused by cholesterol biosynthesis inhibition in liver and by increase of bile acids secretion.4

Terminalia arjuna
This plant has strong antioxidant activity. A study has been made in year 2006, this study shows an antioxidant activity on induced hepatocellular carcinoma in rats. After intraperitoneal administration of N-nitrosodiethylamine and phenobarbital an ethanolic extract of T. arjuna was given per os to hepatocellular carcinoma-bearing rats. Results show significant antioxidant activity against induced liver cancer.5
Another study showed an antioxidant activity, a randomised placebo-controlled study has been made in year 2001. It has been found that extract has not only antioxidant activity, but it has a significant hypocholesterolaemic effect.6

Cichorium intybus extr.
Many studies that investigated antioxidant activity were made. A study in 2001 in vitro has shown protective effect of extract against LDL oxidation.7
More studies investigated hepatoprotective effects of this plant and its extracts. A study in 1998 has investigated influence of extracts on tetrachlormethan induced liver damage in rats. Big decrease of ALT, AST and bilirubine and increase of albumin level was observed in rats, that were treated by extracts. These biochemical evaluations were completed by histopathological analysis of liver tissue.8 Analogical study has been made in 2003, another extracts of this plants were used. This study showed, that methanolical fraction was most effective, this fraction showed effect comparable to silymarin, histopathological analysis of tissue showed in case of this extract almost total normalisation of tissue, there was observed neither tissue lipidosis, nor necrosis.9

Capparis spinosa
Some studies were made to show antioxidant activity of Capparis spinosa. Two studies have been made in year 2002. Both studies showed the antioxidant activity, this activity is caused by content of flavonoids.10,11
A compound (p-Methoxy benzoic acid) isolated from the methanolic soluble fraction of the aqueous extract of Capparis spinosa was found to possess significant antihepatotoxic activity against carbontetrachloride and paracetamol induced hepatotoxicity in vivo and thioacetamide and galactosamine induced hepatotoxicity in isolated rat hepatocytes.12

Emblica officinalis extr.
This plant is well known as a strong antioxidant. Many studies investigated this effect. Hepatoprotective activity of tannins from this plant was investigated in rats. The rats became a fraction of fresh juice in dosis 10, 20 and 50 mg/kg body weight for 10 days. After proposal of iron dose (30 mg/kg body weight) there was observed hepatoprotective effect analogic to the silymarin effect.13
An effect of this plant was investigated in cyclophosphamid treated mice. The extract was given to the mice for 10 days (dose 100 mg/kg body weight) per os. It turned out that the extract has protective influence on liver and kidney.14
The effect of extract on human tumor cells was investigated in vitro. It turned out that pyrogallol contained in extract has antiproliferative effects. Various tumor cells were used for this experiment.15
Alcoholical extracts have gastroprotective effects. Two studies were made, the first with methanolical extract, the second with ethanolical extract. Both studies were made in rats. Methanolical extract was given to the rats, by that the gastric ulcerations were made by various effects (aspirin, ethanol, stress). After treatment of extract (dose 20 mg/kg body weight) the rats were after 5-10 days healthy, by lower doses a gastroprotective effect was observed.16 Ethanolical extract was given in dosis 250 and 500 mg/kg body weight in the same indications. All types of ulcerations were cured, and an antisecretion effect of extract was observed.17

Achillea millefolium
The in vitro antioxidant activities of the essential oil and methanol extracts of Achillea millefolium were investigated. The polar phase of extract and the essential oil showed antioxidant activity in vitro.18 Some studies showed that the plant contains flavonoids, important antioxidants.19

Tamarix gallica
One study from year 2006 has shown that Tamaris gallica contains phenolics and phenolics acids. These substances have an antioxidant activity.20

Andrographis paniculata
Many studies that investigated antioxidant and hepatoprotective activity of this plant and its extracts were made. Two studies have been made in 2001, both of them in mice. The studies investigated influence of extracts on many liver enzymes (antioxidant enzymes, drug metabolism enzymes). Increased activity was showed, especially of antioxidant enzymes, but also of drug metabolism enzymes. The studies showed antioxidant and hepatoprotective activity, and chemopreventive potential against chemotoxicity including carcinogenity.21,22


Tabebuia sp.
Some species of this genus are widely used (T. serratifolia, impetiginosa, avellanedae). Many studies has been made during last 10 years. Some of them investigate an antioxidant activity of Tabebuia.23 A study that has been made in year 2006 shows new phenolic glycosides isolated from Tabebuia bark.24 Phenolic glycosides are very important substances with antioxidant activity.
This plant has some antibacterial activity, it can help by some diseases of digestive system. A study that has been made in year 2005 shows that anthraquinone-2-carboxylic acid and lapachol make selective inhibition of some microorganisms. They inhibited Clostridium paraputrificum, Clostridium perfringens and Escherichia coli and didn´t inhibit Bifidobacterium adolescentis, Bifidobacterium bifidum, Bifidobacterium infantis, Lactobacillus acidophilus, and Lactobacillus casei.25 Very important is a study from year 2006, it shows that Tabebuia can help with Helicobacter pylori eradication.26


Sources:

1. Chatterjee, M., Sarkar, K., Sil, P.C.: Herbal (Phyllanthus niruri) protein isolate protects liver from nimesulide induced oxidative stress. Patophysiology, 2006, 13(2), 95-102.
2. Harish, R. ,Shivanandappa, T.: Antioxidant activity and hepatoprotective potential of Phyllanthus niruri. Food Chem., 2006, 95 (2), 180-5.
3. Venkateswaran, P.S., Millman, I., Blumberg, B.S.: Effects of an extract from Phyllanthus niruri on hepatitis B and woodchuck hepatitis viruses: in vitro and in vivo studies. Proc Natl Acad Sci, 1987, 84(1): 274–8.
4. Khanna, A.K., Rizvi, F., Chander, R.: Lipid lowering activity of Phyllanthus niruri in hyperlipemic rats. Journal of Ethnopharm., 2002, 82 (1), 19-22.
5. Sivalokanathan, S., Ilayaraja, M., Balasubramanian, M.P.: Antioxidant activity of Terminalia arjuna bark extract on N-nitrosodiethylamine induced hepatocellular carcinoma in rats. Mol. Cell Biochem., 2006, 281 (1-2), 87-93.
6. Gupta, R., Singhal, S., Goyle, A., Sharma, V.N.: Antioxidant and hypocholesterolaemic effects of Terminalia arjuna tree-bark powder: a randomised placebo-controlled trial. J. Assoc. Physicians India, 2001, 49, 231-5.
7. Kim, T.W., Yang, K.S.: Antioxidative effects of cichorium intybus root extract on LDL (low density lipoprotein) oxidation. Arch. Pharm. Res., 2001, 24, 431-436.
8. Zafar, R., Ali, S.M.: Anti-hepatotoxic effects of root and root callus extracts of Cichorium intybus L. J. of Ethnopharmacol., 1998, 63, 227-231.
9. Bahar, A., Al-Howiriny, T.A., Siddiqui, A.B.: Antihepatotoxic activity of seeds of Cichorium intybus. J. of Ethnopharmacol., 2003, 87, 237-240.
10. Bonina, F., Puglia, C., Ventura, D., Aquino, R., Tortora, S., Sacchi, A., Saija, A., Tomaino, A., Pellegrino, M.L., de Caprariis, P.: In vitro antioxidant and in vivo photoprotective effects of a lyophilized extract of Capparis spinosa L buds. J Cosmet Sci., 2002, 53(6),321-35.
11. Germano, M.P, De Pasquale, R., D'Angelo, V., Catania, S., Silvari, V., Costa, C.: Evaluation of extracts and isolated fraction from Capparis spinosa L. buds as an antioxidant source. J Agric Food Chem., 2002, 50(5),1168-71.
12. Gadgoli, C., Mishra, S.H.: Antihepatotoxic activity of p-methoxy benzoic acid from Capparis spinosa. J Ethnopharmacol., 1999, 66(2),187-92.
13. Bhattacharya A., Kumar M., Ghosal S., Bhattacharya S.K.: Effect of bioactive tannoid principles of Emblica officinalis on iron-induced hepatic toxicity in rats. Phytomedicine, 2000, 7, 173-175.

14. Haque R., Bin-Hafeez B., Ahmad I., Parvez S., Pandey S., Raisuddin S.: Protective effects of Emblica officinalis Gaertn. in cyclophosphamide-treated mice. Hum. Exp. Toxicol., 2001, 20, 643-650.


15. Khan M.T., Lampronti I., Martello D., Bianchi N., Jabbar S., Choudhuri M.S., Datta B.K., Gambari R.: Identification of pyrogallol as an antiproliferative compound present in extracts from the medicinal plant Emblica officinalis: Effects on in vitro cell growth of human tumor cell lines. Int. J. Oncol., 2002, 21, 187-192.
16. Sairam K., Rao Ch.V., Babu M.D., Kumar K.V., Agrawal V.K., K Goel R.K.: Antiulcerogenic effect of methanolic extract of Emblica officinalis: an experimental study. J. Ethnopharmacol., 2002, 82, 1-9.
17. Al-Rehaily A.J., Al-Howiriny T.A., Al-Sohaibani M.O., Rafatullah S.: Gastroprotective effects of Amla (Emblica officinalis) on in vivo models in rats. Phytomedicine, 2002, 9, 515-522.
18. Candan, F.,Unlu, M.,Tepe, B., Daferera, D., Polissiou, M., Sökmen, A., Akpulat, H.A.: Antioxidant and antimicrobial activity of the essential oil and methanol extracts of Achillea millefolium subsp. millefolium Afan. (Asteraceae). Journal of Ethnopharmacol., 2003, 87 (2-3), 215-20.
19. Gherase, F., Miron, A., Zagnat, M., Hancianu, M., Stanescu, U., Grigorescu, E.: Phytochemical investigations regarding the flavonoidic compounds of some species belonging to the Achillea millefolium L. group. Rev. Med. Chi.r Soc. Med. Nat. Iasi., 2004, 108(1),177-80.
20. Djurdjevic, L., Mitrovic, M., Pavlovic, P., Gajic, G., Kostic, O.: Phenolic acids as bioindicators of fly ash deposit revegetation. Arch Environ Contam Toxicol., 2006, 50(4), 488-95.
21. Singh, R.P., Banerjee, S., Rao, A.R.: Modulatory influence of Andrographis paniculata on mouse hepatic and extrahepatic carcinogen metabolizing enzymes and antioxidant status. Phytother. Res., 2001, 15, 382-390.

22. Trivedi, N.P., Rawal, U.M.: Hepatoprotective and antioxidant property of Andrographis paniculata (Nees) in BHC induced liver damage in mice.Indian J. Exp. Biol., 2001, 39, 41-46.
23. Park, B.S., Lee, K.G., Shibamoto, T., Lee, S.E., Takeoka, G.R.: Antioxidant activity and characterization of volatile constituents of Taheebo (Tabebuia impetiginosa Martius ex DC). J Agric Food Chem, 2003, 51(1),295-300.
24. Warashina, T., Nagatani, Y., Noro, T.: Constituents from the bark of Tabebuia impetiginosa. Chem Pharm Bull (Tokyo), 2006, 54(1),14-20.
25. Park, B.S., Kim, J.R., Lee, S.E., Kim, K.S., Takeoka, G.R., Ahn, Y.J., Kim, J.H.: Selective growth-inhibiting effects of compounds identified in Tabebuia impetiginosa inner bark on human intestinal bacteria. J Agric Food Chem, 2005, 53(4),1152-7.
26. Park, B.S., Lee, H.K., Lee, S.E., Piao, X.L., Takeoka, G.R., Wong, R.Y., Ahn, Y.J., Kim, J.H.: Antibacterial activity of Tabebuia impetiginosa Martius ex DC (Taheebo) against Helicobacter pylori. J Ethnopharmacol., 2006, 105(1-2),255-62.

up