Dr. Řádek

Azadirachta Body Lotion

Use of this product line is recommended especially for individuals with problematic skin prone to inflammatory and bacterial diseases of the skin, eczema, and psoriasis.

Packaging:

Dose 250ml

Composition:

Aqua, Paraffinum Perliquidum, Azadirachta Indica Extr., Petrolatum, Glycerin, Cetyl and Stearyl Alcohol, Alkyl Benzoane, Dimeticone, Urea, Sweet Almond Oil, Glycine Soja Oil, D-Panthenol, Dehydroacetic Acid, Xanthan Gum, Tocopherol, Retinol Palmitane, Ascorbyl Palmitane, Polyacrylamide, Glycereth-2 Cocoate, Isoparaffin, Sodium Laureth Sulfate, Laureth-4,BHT, Benzyl Alcohol, Parféme Celesty, Jasmonal, Linalol, Alcool Benzylique, Isorandeine, Lilia, Limonene

Recommended Dosage:

Apply the product to the skin and massage in gently. Since the product contains pure plant extracts, only a small amount should be applied to avoid color staining of clothes.

Effects:

Body lotion with Azadirachta indica (Neem) extract helps maintain a healthy appearance of the skin with its strong antioxidative properties. Active ingredients contained in this plant have strong antiseptic, antifungal, anti-inflammatory, and antibacterial effects. Body lotion regulates the size of skin pores, and refines and smoothes the surface of skin. In addition, it has a beneficial effect on the skin's moisture management and regulates the optimal moisture balance of the skin. Use of this product line is recommended especially for individuals with problematic skin prone to inflammatory and bacterial diseases of the skin, eczema, and psoriasis.

More...:

Azadirachta indica
Mgr. Katerina Horackova, Clinical department director
It is a tree amounting to 16 m high. Leaves are folded, oval-lanced and spotted. Bark is dun, wrinkled. Flowers are small, white. It grows in tropical areas of India and Sri Lanka, appearance was noted in Indonesia, Australia and West Africa.1
Bark and leaves contain tannin and essential oil, seeds contain triterpenes and tetranortriterpenes (limonoids and protolimonoids), especially nimboline A and B, nimbine, gedunine.1
Recently utilisation of leave extracts in additional therapy of some carcinoma kinds has been investigated. It was found in albino mice that the extract has a chemopreventive effect. Animals got two different doses (250 and 500 mg/kg) of ethanolical extract. Enzyme phases I and II, antioxidant enzymes, lactatdehydrogenase and lipidperoxidase activity ang glutathion content in liver was monitored. Benzo(a)pyrene and 7,12-dimethylbenz(a)anthracene were used as cancerogenic substances.. Significant increase of enzyme activities and decrease of tumour incidence was observed.2 Ehrlich carcinoma and B16 melanoma growth inhibition was investigated in mice. Mice got aqueous extract before or after tumour cells inoculation. Significant tumour cells growth inhibition was observed in mice that got the extract before inoculation. In vitro it was found that the effect is probably caused by immune response influence (increased activity of CD 4+ and CD 8+ T cells).3 In another in vitro model probable cytotoxic activity of azadiron 1 and two its semisyntetic derivatives was confirmed.4 In year 2006 some another studies dealing with cancerogenesis has been made. One of them (made in mice) investigated inhibition effect of leave extract on skin carcinoma induced by 7,12-dimethylbenz(a)anthracene. Mice were separated into four groups. First group was a control group. Groups II and IV got 7,12-dimethylbenz(a)anthracene subcutaneously for carcinoma induction. Groups III and IV got three times a week aqueous extract. In groups II and IV skin carcinomas evolved. In group IV significant decrease of tumour size was observed as compared to group II. In tumour tissue significant increase of lipid peroxidation was observed and in skin tissue of all monitored groups glutathion content and antioxidant enzyme activity (glutathionreductase and glutathionperoxidase) increased as compared to group I. Role of extract in cancerogenesis inhibition is still discussed. 5 Next study made in the same kind of mice investigated liver status in mice bearing skin tumours. Tumours were invoked in the same way as in previous study and the same type of extract was used. It was observed that skin tumour induction causes liver damage characterised by decrease of hepatosomatic index and increase of enzymes signalizing liver damage. During treatment with extract significant reverse of above-mentioned marks was observed. In liver tissue of mice bearing tumour oxidative stress increase was observed – lipid peroxidation increased, reduced glutathion level and enzyme activity (glutathionreductase, glutathipnperoxidase, glutathion-S-transferase) decreased. Extract administration had reverse effect – oxidative stress was reduced because of lipid peroxidation decrease and enzyme antioxidant activity increase. 6
Next investigations have been made in connection with gastric ulceration treatment. In year 2002 a study with bark extract has been made. In vitro extract inhibits H+K+ATPase activity comparable to omeprazol. In vivo results differed in type of ulceration origin. By increased secretion of hydrochloric acid caused by pylorus ligature extract worked comparable to ranitidin, but in comparison with omeprazol extract was more effectively. By treatment of ulcerations caused by stress extract was more effectively than ranitidin and comparable to omeprazol. It was found that extract protects mucose before oxidative damage by significant lipid peroxidase inhibition and free radical scavenging more effectively, than antioxidants with antiulcerous effect (vitamin E, desferoxamin).7 Recently a study in mice has been made, in this study antiulcerous effect of extract has been investigated. Extract was given in doses of 100-800 mg/kg p.o., 100-250 mg/kg i.p. Ulcerations were induced by indomethacine in dose of 40 mg/kg i.p. Significant ulceration inhibition was observed, in doses of 800 mg/kg p.o. and 250 mg/kg i.p. protective effect was 100%. Working of extract itself and in combination with histamine (1mg/kg) and cimetidine (0,12 mg/kg) on gastric secretion. Significant inhibition of both basal and induced by histamine was observed in dose of 250 mg/kg. Effect of extract was intensified by cimetidine. 8
In aqueous leave extract a dose independent negative inotropic and chronotropic effect was found. A study was made in isolated frog and rabbit heart muscles. In rabbit heart increase of coronary flow was observed. The effect wasn´t blocked neither by atropine, nor by mepyramine.9
Very interesting study investigating neuroprotective effect of Azadirachta indica has been made in year 2005. The effect on brain tissue after reperfusion and long hypoperfusion was investigated. In the first case after 30 min hypoperfusion and following 45 min reperfusion an increase of lipid peroxidation, superoxiddismutase activity and T-SH groups formation in tissue was observed. If Azadirachta indica (500 mg/kg/day for 7 days) was administered before hypo- and reperfusion, above-mentioned processes have been more gentle. Moreover ascorbic acid level in tissue was increased. In the second case experimental animals were exposed to hypoperfusion for 2 weeks, significant histopatological and behavioral changes were observed. If Azadirachta indica (500 mg/kg/day for 15 days), was administered, significant reduction of all monitored pathological parameters was observed. 10
Azadirachta indica is widely topical used for treatment of some kinds of skin diseases, especially acne and psoriasis. Its effects were studied in vitro. Polymorphonuclear leukocytes and monocytes were added to bacteria Propionibacterium acnes and to some samples an extract was added. Inflammation substances (reactive oxygen radicals, interleukine 8 and tumour necrosis factor a were observed. It was found that Azadirachta indica inhibits significantly production of reactive oxygen radicals from polymorphonuclear leukocytes and shows maximal supression of interleukine 8 and tumour necrosis factor a. 11

Sources:
1. PDR® for Herbal Medicines, Medical Economics Company, New Jersey, 1998, s. 682.
2. Dasgupta, T., Banerjee, S., Yadava, P.K., Rao, A.R.: Chemopreventive potential of Azadirachta indica (Neem) leaf extract in murine carcinogenesis model systems. J. Ethnopharmacol., 2004, 92, s. 23-36.
3. Baral, R., Chattopadhyay, U.: Neem (Azadirachta indica) leaf mediated immune activation causes prophylactic growth inhibition of murine Ehrlich carcinoma and B16 melanoma. Int. Immunopharmacol., 2004, 4, s. 355-366.
4. Nanduri, S., Thunuguntla, S.S., Nyavanandi, V.K., Kasu, S., Kumar, P.M., Ram, P.S., Rajagopal, S., Deevi, D.S., Rajagopalan, R., Venkateswarlu, A.: Biological investigation and structure-activity relationship studies on azadirone from Azadirachta indica A. Juss. Bioorg. Med. Chem. Lett., 2003, 13, s. 4111-4115.
5. Koul, A., Mukherjee, N., Gangar, S.C.: Inhibitory effects of Azadirachta indica on DMBA-induced skin carcinogenesis in Balb/c mice. Mol. Cell. Biochem., 2006, 283(1-2), s. 47-55.
6. Koul, A., Ghara, A.R., Gangar, S.C.: Chemomodulatory effects of Azadirachta indica on the hepatic status of skin tumor bearing mice. Phytother. Res., 2006, 20(3), s. 169-77.
7. Bandyopadhyay, U., Biswas, K., Chatterjee, R., Bandyopadhyay, D., Chattopadhyay, I., Ganguly, C.K., Chakraborty. T., Bhattacharya. K., Banerjee, R.K.: gastroprotective effect of Neem (Azadirachta indica) bark extract: possible involvement of H(+)-K(+)-ATPase inhibition and scavening of hydroxyl radical. Life Sci., 2002, 71, 2845-2865.
8. Raji, Y., Ogunwande, I.A., Osadebe, C.A., John, G.: Effects of Azadirachta indica extract on gastric ulceration and acid secretion in rats. J. Ethnopharmacol., 2004, 90, s. 167-170.
9. Khosla, P., Gupta, A., Singh, J.: A study of cardiovascular effects of Azadirachta indica (Neem) on isolated perfused heart preparations. Indian J. Physiol. Pharmacol., 2002, 46, s. 241-244.
10. Yanpallewar, S., Rai, S., Kumar, M., Chauhan, S., Acharya, S.B.: Neuroprotective effect of Azadirachta indica on cerebral post-ischemic reperfusion and hypoperfusion in rats. Life Sci., 2005, 76(12), s. 1325-38.
11. Jain, A., Basal, E.: Inhibition of Propionibacterium acnes-induced mediators of inflammation by Indian herbs. Phytomedicine, 2003, 10, s. 34-38.

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