Dr. Řádek

ImunoProtect Tbl

Food Supplement with Herbal Extracts

Packaging:

Dose 100 tablets

Composition:

Composition of 1 tablet 600mg: Ashwagandha - Withania somnifera extr.150mg, Guduchi - Tinospora cordifolia extr.150mg, Microcrystalline cellulose, Indian Gooseberry - Amalaki - Emblica officinalis extr.50mg, Ubos - Spondias mombin extr.50mg, Magnesium stearate
One tablet contains: stand.extracts Withania somnifera 150mg, Tinospora cordifolia 150mg, Emblica officinalis 50mg, Spondias mombin 50mg

Recommended Dosage:

Adults 1 tablet twice a day
Children from 12 1 tablet once a day

Effects:

It supports certain functions of the organism and so strengthens own defensiveness of the organism. It stimulates the activity of phagocyting white blood cells and so supports the mechanisms of non-specific immunity. It reduces the risk of origination mainly diseases of bacteriological and viral origin caused by the weakening of the organism by outer influences.

More...:

ImunoProtect tbl
Mgr. Katerina Horackova, Clinical department director

This preparative strenghtens natural organism striking power. It stimulates phagocytes activity. It decreases risk of bacterial and viral diseases caused by organism attenuation.
It contents extracts of Withania somnifera, Tinospora cordifolia, Emblica officinalis, Spondias mombin.

Withania somnifera
In year 2003 some studies investigating adaptogenic and anti-stress properties have been made. The adaptogenic activity was investigated against a rat model of chronic stress, rats got Withania somnifera (25 and 50mg/kg) p.o. or Panax ginseng (100mg/kg p.o.). The results show that Withania somnifera has (like Panax ginseng) significant antistress adaptogenic activity.1 Another study used isolated 1-oxo-5beta, 6beta-epoxy-witha-2-ene-27-ethoxy-olide for investigating. Stress-related indices were evaluated (creatine phosphokinase activity, lactate dehydrogenase activity, corticosterone levels, lipid peroxidation). There was a significant decrease in levels of all observed indices.2
A study investigating antiulcer and antioxidant activity of Asparagus racemosus and Withania somnifera has been made in year 2005. Results showed that both extracts have antiulcer activity, Asparagus is more effective against indomethacine-induced ulcers, Withania against stress-induced ulcers. Both extracts showed high antioxidant activity.3
Some studies investigating immunomodulatory activity have been made in last three years. In year 2004 a study has investigated Immune response modulation to DPT (Diphtheria, Pertussis, Tetanus) vaccine by aqueous extract of Withania somnifera. Animals imunized with vaccine were treated with an extract for 15 days. Significant increase of antibody titers to B. pertussis was observed. Imunized animals (treated and untreated with the extract) got live B. pertussis cells and were observed for 14 days. The results showed that there was significant increase in antibody titres of B. pertussis, mortality reduction and improved health status in treated animals.4 Immunomodulatory effect was observed in next study, the extract was administered to mice with benzo(a)pyrene induced lung carcinoma together with paclitaxel. Immune dysfunction has been found to be associated with cancer and chemotherapy. Animals were treated with 400 mg/kg of extract for 30 days, significant changes of immunocompetent cells, immune complexes and immunoglobulins levels were observed. The toxic side effects on the immune system were more reversible and more controllable by Withania somnifera.5
Very interesting is, that Withania somnifera has immunosupressive effects on experimental induced inflammation, it showed potent inhibitory activity towards the complement system, mitogen induced lymphocyte proliferation and delayed-type hypersensitivity reaction. It can be used for treatment of diseases where autoimmunne reactions play important role.6

Tinospora cordifolia
This plant is an important antioxidant. Many studies investigating this effect were made. Two studies made in year 2002 have shown that extract and isolated polysaccharides can protect against radiation because of free radical scavenging.7,8 Tinospora has been investigated in year 2004 as an antioxidant useful by ischemic brain damage therapy. The study showed high antioxidant properties.9 Next studies showed high effect on antioxidant enzymes in liver and kidney.10,11

Emblica officinalis
This plant is well known as a strong antioxidant. Many studies investigated this effect. Hepatoprotective activity of tannins from this plant was investigated in rats. The rats became a fraction of fresh juice in dosis 10, 20 and 50 mg/kg body weight for 10 days. After proposal of iron dose (30 mg/kg body weight) there was observed hepatoprotective effect analogic to the silymarin effect.12
Protective effect of Emblica officinalis ethanolic extract against induced genotoxicity has been investigated in year 2004. This study was made in mice, genotoxicity was induced by 7,12-dimethylbenz(a)anthracene. It was found that liver antioxidants, such as glutathione (GSH), glutathione peroxidase (GPx), glutathione reductase (GR) and detoxifying enzyme glutathione-S-transferase (GST) were increased in group treated with extract. There was a dose-dependent effect of the extract against the genotoxin with the maximum effect at 500 mg/kg.13
The antioxidant properties on some next organs were investigated. One study from year 2004 has shown that Emblica can protect myocardium against oxidative damage caused by ischaemic-reperfusion injury, this study has been made in rats. The results indicate that chronic Emblica officinalis administration causes myocardial adaptation by augmenting endogenous antioxidants and protects rat hearts from oxidative stress associated with ischemic-reperfusion injury.14
Alcoholical extracts have gastroprotective effects. Two studies were made, the first with methanolical extract, the second with ethanolical extract. Both studies were made in rats. Methanolical extract was given to the rats, by that the gastric ulcerations were made by various effects (aspirin, ethanol, stress). After treatment of extract (dose 20 mg/kg body weight) the rats were after 5-10 days healthy, by lower doses a gastroprotective effect was observed.15 Ethanolical extract was given in dosis 250 and 500 mg/kg body weight in the same indications. All types of ulcerations were cured, and an antisecretion effect of extract was observed.16

Spondias mombin
This plant was investigated because of its antibacterial and antiviral properties. In year 1992 a study has been made, this study showed that leaves and stems of Spondias mombin contain 2-O-Caffeoyl-(+)-allohydroxycitric acid and chlorogenic acid butyl ester, two compounds with antiviral activity. It was found that these two compounds show activity against herpes simplex virus.17
In year 1994 a compound (anacardic acid derivative) has been isolated from Spondias mombin, this compound shows beta-lactamase inhibitory activity.18 In the same year another study has shown that Spondias mombin contains a series of 6-alkenyl-salicylic acids. They were isolated from the ethanolic extract of leaves and stems of Spondias mombin. These compounds have a pronounced antibacterial effect against Bacillus cereus, Streptococcus pyogenes, and Mycobacterium fortuitum.19 A study from year 1999 has shown that the leaf extract of Spondias mombin has wide antibacterial activity comparable to ampicillin and gentamycin.20

Sources
1. Bhattacharya, S.K., Muruganandam, A.V.: Adaptogenic activity of Withania somnifera: an experimental study using a rat model of chronic stress. Pharmacol. Biochem. Behav., 2003, 75(3), 547-55.
2. Kaur, P., Sharma, M., Mathur, S., Tiwari, M., Divekar, H.M., Kumar, R., Srivastava, K.K., Chandra, R.: Effect of 1-oxo-5beta, 6beta-epoxy-witha-2-ene-27-ethoxy-olide isolated from the roots of Withania somnifera on stress indices in Wistar rats. J. Altern. Complement. Med., 2003, 9(6), 897-907.
3. Bhatnagar, M., Sisodia, S.S., Bhatnagar, R.: Antiulcer and Antioxidant Activity of Asparagus racemosus WILLD and Withania somnifera DUNAL in Rats. Ann. N. Y. Acad. Sci., 2005, 1056, 261-78.
4. Gautam, M., Diwanay, S.S., Gairola, S., Shinde, Y.S., Jadhav, S.S., Patwardhan, B.K.: Immune response modulation to DPT vaccine by aqueous extract of Withania somnifera in experimental system. Int. Immunopharmacol., 2004, 4(6), 841-9.
5. Senthilnathan, P., Padmavathi, R., Banu, S.M., Sakthisekaran, D.: Enhancement of antitumor effect of paclitaxel in combination with immunomodulatory Withania somnifera on benzo(a)pyrene induced experimental lung cancer. Chem. Biol. Interact., 2006, 159(3),180-5.
6. Rasool, M., Varalakshmi, P.: Immunomodulatory role of Withania somnifera root powder on experimental induced inflammation: An in vivo and in vitro study. Vascul. Pharmacol., 2006, 44(6), 406-10.
7. Subramanian, M., Chintalwar, G.J., Chattopadhyay, S.: Antioxidant properties of a Tinospora cordifolia polysaccharide against iron-mediated lipid damage and gamma-ray induced protein damage. Redox. Rep., 2002,7(3), 137-43.
8. Goel, H.C., Prem Kumar, I., Rana, S.V.: Free radical scavenging and metal chelation by Tinospora cordifolia, a possible role in radioprotection. Indian J. Exp. Biol., 2002, 40(6), 727-34.
9. Rawal, A., Muddeshwar, M., Biswas, S.: Effect of Rubia cordifolia, Fagonia cretica linn, and Tinospora cordifolia on free radical generation and lipid peroxidation during oxygen-glucose deprivation in rat hippocampal slices. Biochem. Biophys. Res. Commun., 2004, 324(2), 588-96.
10. Prince, P.S., Padmanabhan, M., Menon, V.P.: Restoration of antioxidant defence by ethanolic Tinospora cordifolia root extract in alloxan-induced diabetic liver and kidney. Phytother. Res., 2004, 18(9),785-7.
11. Singh, R.P., Banerjee, S., Kumar, P.V., Raveesha, K.A., Rao, A.R.: Tinospora cordifolia induces enzymes of carcinogen/drug metabolism and antioxidant system, and inhibits lipid peroxidation in mice. Phytomedicine, 2006, 13(1-2),74-84.
12. Bhattacharya A., Kumar M., Ghosal S., Bhattacharya S.K.: Effect of bioactive tannoid principles of Emblica officinalis on iron-induced hepatic toxicity in rats. Phytomedicine, 2000, 7, 173-175.
13. Banu, S.M., Selvendiran, K., Singh, J.P., Sakthisekaran, D.: Protective effect of Emblica officinalis ethanolic extract against 7,12-dimethylbenz(a) anthracene (DMBA) induced genotoxicity in Swiss albino mice. Hum. Exp. Toxicol., 2004, 23(11), 527-31.
14. Rajak, S., Banerjee, S.K., Sood, S., Dinda, A.K., Gupta, Y.K., Gupta, S.K., Maulik, S.K.: Emblica officinalis causes myocardial adaptation and protects against oxidative stress in ischemic-reperfusion injury in rats. Phytother. Res., 2004, 18(1),54-60.
15. Sairam K., Rao Ch.V., Babu M.D., Kumar K.V., Agrawal V.K., K Goel R.K.: Antiulcerogenic effect of methanolic extract of Emblica officinalis: an experimental study. J. Ethnopharmacol., 2002, 82, 1-9.
16. Al-Rehaily A.J., Al-Howiriny T.A., Al-Sohaibani M.O., Rafatullah S.: Gastroprotective effects of Amla (Emblica officinalis) on in vivo models in rats. Phytomedicine, 2002, 9, 515-522.
17. Corthout, J., Pieters, L.,Claeys, M., Vanden Berghe, D., Vlietinck, A.: Antiviral caffeoyl esters from Spondias mombin. Phytochemistry, 1992, 31, (6), s. 1979-81.
18. Coates, N.J., Gilpin, M.L., Gwynn, M.N., Lewis, D.E., Milner, P.H., Spear, S.R., Tyler, J.W.: SB-202742, a novel beta-lactamase inhibitor isolated from Spondias mombin. J. Nat. Prod., 1994, 57(5), 654-7.
19. Corthout, J., Pieters, L., Claeys, M., Geerts, S., Vanden Berghe, D., Vlietinck, A.: Antibacterial and molluscicidal phenolic acids from Spondias mombin. Planta Med., 1994, 60(5), 460-3.
20. Abo, K.A., Ogunleye, V.O., Ashidi, J.S.: Antimicrobial potential of Spondias mombin, Croton zambesicus and Zygotritonia crocea. Phytother. Res., 1999, 13(6), 494-7.

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