Dr. Řádek

AnabolProtect Tbl

Food Supplement with Herbal Extracts

Packaging:

Dose 100 tablets

Composition:

Composition of 1 tablet 1000 mg: Polydextrose, Microcrystalline cellulose, Suma -Pfaffia Glomerata extr.120mg, Acerola - Malpighia Glabra extr.100mg, Glutarcarob, Tribulus Terrestris extr., Bitter Orange - Citrus Aurantium extr.50mg, carnitine 50mg, Beta-Carotene 30mg , Magnesium Stearate, Maté -Ilex Paraquariensis extr.20mg
One tablet contains: stand.extracts Pfaffia glomerata 120mg, Malpighia glabra 100mg, Tribulus terrestris 70mg , Citrus aurantium 50mg, Ilex paraquariensis 20mg, Karnitin 50mg, Beta-Carotene 10% 30mg

Recommended Dosage:

Adults: 3 times a day 1 pastille let dissolve in mouth

Effects:

The product favourably acts on the locomotive organs by improving their output. It increases the ability of some tissues/ mainly muscles/ to produce energy. It further accelerates the lipolysis and increases the muscle metabolism. It does not come to the reduction of muscle mass during this process. Physical and psychical activities of the organism are increased and so is its resistance against stress and increases its physical and psychical output.

More...:

AnabolProtect
Mgr. Katerina Horackova, Clinical department director

This preparative works favourably on locomotive organs, it helps to improve achievement. It improves ability of some tissues (especially muscles) to produce energy. It helps to lipolysis acceleration and muscle metabolism increase, no muscle mass decrease happens. It helps to increase physical and mental activity. It helps to increase stress-resistance and resistance against high physical and mental achievement.
It contains extracts of Pfaffia glomerata, Malpighia glabra, Tribulus terrestris, Citrus aurantium, Ilex paraquariensis, than carnitine, glutarcarobe, beta-carotene.

Pfaffia glomerata
Some studies investigating effects of this plant were made. A study that has been made in year 2004 has investigated influence on learning and memory. This study was made in mice. They got 100 mg/kg of extract for 150 days p.o. (control group was treated with water), young and old mice were used. It was found that the extract promoted an increase of both learning and memory of old mice.1
Two studies have been made in years 2005 and 2006, these studies have investigated analgesic, antiinflammatory and anti-oedematogenic properties. The first study was made in rats and mice. The extract was assessed in the carragenan-induced rat paw oedema. Rats got 100, 200 and 300 mg/kg, the effect was dose dependent. At the same doses the extract inhibited acetic acid-induced writhing in mice, no dose response correlation was found.2 The second study was made in mice. The oral or intraperitoneal administration of 1, 10, 30, 100 or 300 mg/kg reduced carragenan-induced paw oedema dose dependently.The extract inhibited also oedemas induced by histamine, serotonin, bradykinin, substance P and bacterial lipopolysaccharide. It was found that the effect is caused by stimulation of endogenous nitric oxide production followed by soluble guanylatcyclase activation.3

Malpighia glabra
This plant is well-known because of vitamin C content. In year 1997 a study has been made, this study has investigated content of vitamin C in this plant. It was found that pulp contains 1,79 g/100 g of vitamin C.4
Vitamin C is very important water-soluble vitamin with strong antioxidant activity. Ascorbic acid as a electron donor is important reducer in many intra- and extracellular reactions. It is a co-factor or co-substrate of 8 enzymes. It is important for collagen, carnitine and catecholamine synthesis. Mono- and dioxygenase activities (peptide amidation, tyrosine metabolism) and cholesterol-7a-monooxygenase activity are dependent on receiving and serum concentration of vitamin C. Recently the main role of vitamin C is the protection against free radicals.5

Tribulus terrestris
Many studies investigating effects of this widely used plant have been made in last years. This plant has antihypertensive and vasodilator effects, these effects were investigated in some studies. In year 2003 a study of antihypertensive mechanism of Tribulus terrestris has been made in rats. There were four groups of rats – control, sham, operated or hypertensive and tribulus treated hypertensive group. The treated group got 10 mg/kg of lyophilized aqueous extract for 4 weeks. ACE activity in aorta, heart, kidney and lung and blood pressure were measured. It was found that ACE activity in all tissues of tribulus treated rats was significantly lower than that of hypertensive non-treated rats. The systolic blood pressure of tribulus treated rats was significantly decreased compared to non-treated rats.6 Another study made in rats in year 2006 has shown that the aqueous and methanolic extracts have significant antihypertensive activity in spontaneously hypertensive rats. The antihypertensive effect is probably caused by direct arterial smooth muscle relaxation possibly involving nitric oxide release and membrane hyperpolarisation. The aqueous extract was more potent in vivo, in vitro the methanolical extract produced dose dependent increase of perfusion pressure.7
Tribulus terrestris has probably androgen increasing property. It has been found in a study from year 2005. Normal and castrated rats were used in this experiment. Effect on nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH-d) activity and androgen receptor (AR) immunoreactivity in rat brain was observed. There was an significant increase in both observed parameters in group treated with tribulus. Chronic treatment increased the NADPH-d positive neurons and AR immunoreactivity. Because increase of both NADPH-d and AR positive neurons is caused either directly by androgens, or by conversion of androgens to oestrogen, this effect of Tribulus is probably caused by its androgen increasing property.8

Citrus aurantium
From fruits adrenergic agonists (D,L-octopamine, D,L-synephrine and tyramine) were isolated.9 There are six possible isomers of synephrine (para, meta, ortho and for each D or L form), some authors have stated that Citrus aurantium contains only p-synephrine, but other authors have stated that it contains only m-synephrine.10
Many studies investigating weight loss have been made in last years. Synephrine has lipolytic effect in human fat cells in high doses.11 Although synephrine increases blood pressure, after administration of Citrus aurantium no effect on blood pressure or another adverse effects were observed.11,12
Some studies showed anxiolytic effect of essential oil of Citrus aurantium in mice. 13

Ilex paraquariensis
This plant has pronounced antioxidant properties. Some studies made in last years has investigated this effect. In year 1996 a study investigating oxidability of human LDL has been made. This study showed that the aqueous extract inhibits LDL autooxidation in plasma.14 In year 2000 another study has been made, this study has investigated antioxidant properties of aqueous extract in rats. The extract inhibited the enzymatic and nonenzymatic lipid peroxidation in rat liver microsomes concentration dependently. The extract also inhibited the peroxide radical-induced peroxidation of red blood cell membranes and exhibited radical scavenging properties toward superoxide anion and 2,2-diphenyl-1-picrylhydrazyl radical.15
Another study from year 2005 has shown cardiporotective effect of Ilex paraquariensis. This study used rat hearts for the investigation. Results showed that extract attenuates the myocardial dysfunction provoked by ischemia and reperfusion and that this cardioprotection involves a decrease of oxidative damage through a nitric oxide-dependent mechanism.16
A study made in year 2006 has investigated influence of Ilex paraquariensis aqueous extract on atherosclerosis progression in rabbits. This study showed that that Ilex paraguariensis extract can inhibit the progression of atherosclerosis in cholesterol-fed rabbits, although it did not decrease the serum cholesterol and antioxidant enzymes.17
Carnitine
Carnitine is an aminoacid that is needed for lipid metabolism. It is not an essencial aminoacid, but carnitine administration improves some tissue ability (especially muscles) to produce energy.

Glutarcarobe
It contains over 80 % of aminoacids, so it is a nutrition component.

Beta carotene
Beta carotene is a provitamin A. It can inactivate excited molecules, this process is called quenching. Very important is the quenching of singlet molecular oxygen, which arises from photochemical reaction, enzymatic or by lipid peroxidation. In most of tissues beta carotene is able to scavenge peroxyl radicals like a-tocoferol. It can play important role in lipid peroxidation prevention. Beta caroten is also the most important vitamin A antecedent.18

Sources:
1. Marques, L.C., Galvao, S.M., Espinola, E., Dias, R.F., Mattei, R., Oliveira, M.G., De Araujo Carlini, E.L.: Psychopharmacological assessment of Pfaffia glomerata roots (extract BNT-08) in rodents. Phytother. Res., 2004, 18(7), 566-72.
2. Neto, A.G., Costa, J.M., Belati, C.C., Vinholis, A.H., Possebom, L.S., Da Silva Filho, A.A., Cunha, W.R., Carvalho, J.C., Bastos, J.K., e Silva, M.L.: Analgesic and anti-inflammatory activity of a crude root extract of Pfaffia glomerata (Spreng) Pedersen. J. Ethnopharmacol., 2005, 96(1-2), 87-91.
3. Teixeira, C.G., Piccoli, A., Costa, P., Soares, L., da Silva-Santos, J.E.: Involvement of the nitric oxide/soluble guanylate cyclase pathway in the anti-oedematogenic action of Pfaffia glomerata (Spreng) Pedersen in mice. J. Pharm. Pharmacol., 2006, 58(5), 667-75.
4. Visentainer, J.V., Vieira, O.A., Matsushita, M., de Souza, N.E.: Physico-chemical characterization of acerola (Malpighia glabra L.) produced in Maringa, Parana State, Brazil. Arch. Latinoam. Nutr., 1997, 47(1), 70-2.
5. Hlubik, P., Opltova, L.: Vitaminy. Grada Publishing, 2004, 144-146.
6. Sharifi, A.M., Darabi, R., Akbarloo, N.: Study of antihypertensive mechanism of Tribulus terrestris in 2K1C hypertensive rats: role of tissue ACE activity. Life Sci., 2003, 73(23), 2963-71.
7. Phillips, O.A., Mathew, K.T., Oriowo, M.A.: Antihypertensive and vasodilator effects of methanolic and aqueous extracts of Tribulus terrestris in rats. J. Ethnopharmacol., 2006, 104(3), 351-5.
8. Gauthaman, K., Adaikan, P.G.: Effect of Tribulus terrestris on nicotinamide adenine dinucleotide phosphate-diaphorase activity and androgen receptors in rat brain. J. Ethnopharmacol., 2005, 96(1-2), 127-32.
9. Pellati, F., Benvenuti, S., Melegari, M., Firenzuoli, F.: Determination of adrenergic agonists from extracts and herbal products of Citrus aurantium L. var. amara by LC. J. Pharm. Biomed. Anal., 2002, 29(6), 1113-9.
10. Allison, D.B., Cutter, G., Poehlman, E.T., Moore, D.R., Barnes, S.: Exactly which synephrine alkaloids does Citrus aurantium (bitter orange) contain? Int. J. Obes. (Lond)., 2005, 29(4), 443-6.
11. Fugh-Berman, A., Myers, A.: Citrus aurantium, an ingredient of dietary supplements marketed for weight loss: current status of clinical and basic research. Exp. Biol. Med. (Maywood)., 2004, 229(8), 698-704.
12. Gougeon, R., Harrigan, K., Tremblay, J.F., Hedrei, P., Lamarche, M., Morais, J.A.: Increase in the thermic effect of food in women by adrenergic amines extracted from citrus aurantium. Obes. Res., 2005, 13(7), 1187-94.
13. Carvalho-Freitas, M.I.R., Costa, M.: Anxiolytic and sedative effects of extracts and essential oil from Citrus aurantium L. Biol. Pharm.Bul., 2002, 25, 1629-33.
14. Gugliucci, A.: Antioxidant effects of Ilex paraguariensis: induction of decreased oxidability of human LDL in vivo. Biochem. Biophys. Res. Commun., 1996 Jul, 224(2), 338-44.
15. Schinella, G.R., Troiani, G., Davila, V., de Buschiazzo, P.M., Tournier, H.A.: Antioxidant effects of an aqueous extract of Ilex paraguariensis. Biochem. Biophys. Res. Commun., 2000, 269(2), 357-60.
16. Schinella, G., Fantinelli, J.C., Mosca, S.M.: Cardioprotective effects of Ilex paraguariensis extract: evidence for a nitric oxide-dependent mechanism. Clin. Nutr., 2005, 24(3), 360-6.
17. Mosimann, A.L., Wilhelm-Filho, D., da Silva, E.L.: Aqueous extract of Ilex paraguariensis attenuates the progression of atherosclerosis in cholesterol-fed rabbits. Biofactors, 2006, 25(1), 59-70.
18. Hlubik, P., Opltova, L.: Vitaminy. Grada Publishing, 2004, 32.

up